Cardiac Operations for Patients with Chronic Liver Disease

(#2001-74848 ... October 11, 2001)

Mehmet Kaplan, MD, Serdar Cimen, MD, Mustafa Sinan Kut, MD, Mahmut Murat Demirtas, MD

Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey

ABSTRACT

Background: Due to the systemic and hepatic effects of cardiopulmonary bypass (CPB), open-heart surgery for patients with chronic liver disease is associated with high mortality and morbidity. In this retrospective study, we present our results of cardiac surgery on patients with non-cardiac cirrhosis.

Methods: Between March 1996 and April 2000, 10 patients with chronic liver disease had open-heart surgery in our institution. Six patients were male and four were female, with a mean age of 57.1 ± 6.85 years. Preoperative severity of liver disease was determined according to Child classification. Four cases (40%) were Child class A and six (60%) were class B. Coronary artery bypass grafting was performed in four cases, and the remaining six operations were for aortic valve replacement (AVR) and/or mitral valve replacement (MVR). Eight of the operations (80%) were performed by using cardiopulmonary bypass and two (20%) were performed as beating heart surgery.

Results: Chest tube drainage and transfusion needs of these patients were three times the average normal values. Three of the patients for whom CPB was used, all of them in Child class B, died. None of the patients in Child class A died. This resulted in an overall mortality rate of 30%, with mortality of 50% for the Child B group. There was no mortality for any patient who underwent cardiac surgery on the beating heart or cardiac surgery of short duration on CPB. Common characteristics of cases that were associated with high morbidity and mortality included increased postoperative hemorrhagic chest tube output, dependency on mechanical ventilation, hepatic and renal failure, gastrointestinal bleeding, and sepsis. None of the patients died of cardiac failure.

Conclusions: Our findings indicate that cardiac operations may be performed with good results for patients suffering from liver disease of mild severity (Child A), but cardiac interventions that include CPB in conjunction with advanced hepatic pathologies are associated with high mortality and morbidity. Cardiac surgery (whether valvular or coronary artery surgery) for patients with chronic liver disease should be carried out with a short duration of CPB or should be done on the beating heart, if possible, in the case of coronary artery surgery.

AUTHOR/ARTICLE INFORMATION

Acknowledgment

The authors thank Abdurrahim Nur Sozudogru, MD, for his contributions to the preparation of the manuscript for this article.

Submitted October 3, 2001; accepted October 11, 2001.

Address correspondence and reprint requests to: Mehmet Kaplan, MD, 67. Ada Kardelen 4-4, D:11 Atasehir ? 81120, Istanbul, Turkey, Phone: +90 216 455 74 52, Fax: +90 216 337 97 19, +90 216 348 93 23, Email: mehmetkaplan@superonline.com