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Coumadin : Drug Interactions
Increased Coumadin® Effect
Highly Probable
- Alcohol (if concomitant liver disease)
- Amiodarone
- Cimetadine
- Clofibrate
- Cotrimoxazole
- Erythromycin
- Fluconazole
- Isoniazid
- Metronidazole
- Miconazole
- Omeprazole
- Phenylbutazone
- Piroxicam
- Propafenone
- Propanolol
- Sulfinpyrazone
Probable
- Acetaminophen (Tylenol®)
- Anabolic steroids
- Aspirin
- Chloral Hydrate
- Ciprofloxacin
- Dextropropoxyphene
- Disulriam
- Quinidine
- Phenytoin (Dilantin®)
- Simvastatin
- Tamoxifen
- Tetracycline
- Influenza vaccine
Possible
- Disopyramide
- 5-Fluorouracil
- Ifosphamide
- Lovastatin
- Metolazone
- Nalidixic Acid
- Norfloxacin
- Ofloxacin
- Topical salicylates
- Sulindac
- Tometin
Doubtful
- Cefamandole
- Cefazolin
- Gemfibrozil
- Heparin
- Indomethacin
- Sulfisoxazole
Decreased Coumadin® Effect
Highly Probably
- Barbiturates
- Carbamazepine
- Chlorodiazepoxide
- Cholestyramine
- Griseofulvin
- Nafcillin
- Rifampin
- Sucralfate
Probable
Possible
- Azathioprine
- Cyclosporine
- Etrelinate
- Trazodone
No Effect
Highly Probable
- Alcohol (if no liver disease)
- Antacids
- Atenolol
- Bumetanide
- Diflunisal
- Enoxacin
- Famotidine
- Felodipine
- Fluoxetine
- Ketorolac
- Metoprolol
- Moricizine
- Naproxen
- Nitrazepam
- Nizatidine
- Psyllium
- Ranitidine
Probable
- Ibuprofen
- Ketoconazole
- Ketoprofen
Doubtful
- Diltiazem
- Tobacco
- Vancomycin
Additional Coumadin Sections:
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